Transplacental Priming of the Human Immune System to Environmental Allergens: Universal Skewing of Initial T Cell Responses Toward the Th2 Cytokine Profile

L. Prescott, Susan; Macaubas, Claudia; J. Holt, Barbara; B. Smallacombe, Troy; Loh, Richard; D. Sly, Peter; G. Holt, Patrick

doi:10.4049/jimmunol.160.10.4730

Public

Transplacental Priming of the Human Immune System to Environmental Allergens: Universal Skewing of Initial T Cell Responses Toward the Th2 Cytokine Profile

Published in The Journal of Immunology • May 1, 1998

Authors:

Susan L. Prescott

Claudia Macaubas

Barbara J. Holt

Abstract

The expression of Th2-skewed immunity against soluble protein Ags present in the normal environment is recognized as the primary cause of allergic inflammation in atopics. In contrast, nonallergic normal individuals display low level Th1-skewed immunity against the same Ags ("allergens"), which is p...

Subject

Immunology

Immune system

Priming (agriculture)

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