Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry

J. Santegoets, Saskia; M. Dijkgraaf, Eveline; Battaglia, Alessandra; Beckhove, Philipp; M. Britten, Cedrik; Gallimore, Awen; Godkin, Andrew; Gouttefangeas, Cécile; D. de Gruijl, Tanja; J. P. M. Koenen, Hans; Scheffold, Alexander; M. Shevach, Ethan; Staats, Janet; Taskén, Kjetil; L. Whiteside, Theresa; R. Kroep, Judith; J.P. Welters, Marij; H. van der Burg, Sjoerd

doi:10.1007/s00262-015-1729-x

Public

Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry

Published in Cancer Immunology Immunotherapy • Jun 27, 2015

Authors:

Saskia J. Santegoets

Eveline M. Dijkgraaf

Alessandra Battaglia

Abstract

Regulatory T cell (Treg)-mediated immunosuppression is considered a major obstacle for successful cancer immunotherapy. The association between clinical outcome and Tregs is being studied extensively in clinical trials, but unfortunately, no consensus has been reached about (a) the markers and (b) t...

Subject

Flow cytometry

Gating

Regulatory T cell

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