The Stem Cell-Associated Antigen CD133 (Prominin-1) Is a Molecular Therapeutic Target for Metastatic Melanoma

Rappa, Germana; Fodstad, Øystein; Lorico, Aurelio

doi:10.1634/stemcells.2008-0601

Public

The Stem Cell-Associated Antigen CD133 (Prominin-1) Is a Molecular Therapeutic Target for Metastatic Melanoma

Published in Stem Cells • Sep 18, 2008

Authors:

Germana Rappa

Øystein Fodstad

Aurelio Lorico

Abstract

CD133 (Prominin-1) is considered the most important cancer stem cell (CSC)-associated marker identified so far, with increased expression in the CSC fraction of a large variety of human malignancies, including melanoma. Here we investigated the effects of CD133 downregulation in vitro and in vivo in...

Subject

Biology

Downregulation and upregulation

Stem cell

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