myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.

K. Joseph, Suresh; P. Thomas, Andrew; J Williams, Rebecca; F. Irvine, Robin; Williamson, John

doi:10.1016/s0021-9258(17)43262-5

Public

myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.

Published in Journal of Biological Chemistry • Mar 1, 1984

Authors:

Suresh K. Joseph

Andrew P. Thomas

Rebecca J Williams

Abstract

The stimulation of hepatocytes by alpha 1-adrenergic agonists and vasoactive peptides results in a mobilization of intracellular Ca2+ which is accompanied by breakdown of phosphatidylinositol 4,5-bisphosphate to release myo-inositol 1,4,5-trisphosphate (Ins(1,4,5)P3). The possible involvement of Ins...

Subject

Inositol

Intracellular

Inositol trisphosphate

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