Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells.

RR, Furman; Z, Asgary; JO, Mascarenhas; HC, Liou; EJ, Schattner

doi:10.4049/jimmunol.164.4.2200

Public

Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells.

Shared by NobleBlocks on Feb 1, 2000 • 12:00 AM UTC

Authors:

Furman RR

Asgary Z

Mascarenhas JO

Abstract

Chronic lymphocytic leukemia (CLL) is an indolent malignancy of CD5+ B lymphocytes. CLL cells express CD40, a key regulator of B cell proliferation, differentiation, and survival. In nonmalignant B cells, CD40 ligation results in nuclear translocation and activation of NF-kappaB proteins. Based on o...

Discussions