Pulmonary Macrophages Attenuate Hypoxic Pulmonary Vasoconstriction via β3AR/iNOS Pathway in Rats Exposed to Chronic Intermittent Hypoxia

Nagai, Hisashi; Kuwahira, Ichiro; O. Schwenke, Daryl; Tsuchimochi, Hirotsugu; Nara, Akina; Ogura, Sayoko; Sonobe, Takashi; Inagaki, Tadakatsu; Fujii, Yutaka; Yamaguchi, Rutsuko; Wingenfeld, Lisa; Umetani, Keiji; Shimosawa, Tatsuo; Yoshida, Kenichi; Uemura, Koichi; T. Pearson, James; Shirai, Mikiyasu

doi:10.1371/journal.pone.0131923

Public

Pulmonary Macrophages Attenuate Hypoxic Pulmonary Vasoconstriction via β3AR/iNOS Pathway in Rats Exposed to Chronic Intermittent Hypoxia

Published in PLoS ONE • Jul 1, 2015

Authors:

Hisashi Nagai

Ichiro Kuwahira

Daryl O. Schwenke

Abstract

Chronic intermittent hypoxia (IH) induces activation of the sympathoadrenal system, which plays a pivotal role in attenuating hypoxic pulmonary vasoconstriction (HPV) via central β1-adrenergic receptors (AR) (brain) and peripheral β2AR (pulmonary arteries). Prolonged hypercatecholemia has been shown...

Subject

Hypoxic pulmonary vasoconstriction

Hypoxia (environmental)

Pulmonary hypertension

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