Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors

Peichev, Mario; J. Naiyer, Afzal; Peixoto Pereira, Daniel; Zhu, Zhenping; J. Lane, William; Williams, Mathew; Oz, Mehmet; J. Hicklin, Daniel; Witte, Larry; A.S. Moore, Malcolm; Rafii, Shahin

doi:10.1182/blood.v95.3.952.003k27_952_958

Public

Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors

Published in Blood • Feb 1, 2000

Authors:

Mario Peichev

Afzal J. Naiyer

Daniel Peixoto Pereira

Abstract

Emerging data suggest that a subset of circulating human CD34(+) cells have phenotypic features of endothelial cells. Whether these cells are sloughed mature endothelial cells or functional circulating endothelial precursors (CEPs) is not known. Using monoclonal antibodies (MoAbs) to the extracellul...

Subject

CD34

Biology

Endothelial stem cell

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