Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene

Gosset, Marjolaine; Berenbaum, Françis; Levy, A.; Pigenet, Audrey; Thirion, Sylvie; Jl, Saffar; Jacques, C.

doi:10.1186/ar2024

Public

Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene

Published in Arthritis Research & Therapy • Jul 27, 2006

Authors:

Marjolaine Gosset

Françis Berenbaum

A. Levy

Abstract

Knee osteoarthritis (OA) results, at least in part, from overloading and inflammation leading to cartilage degradation. Prostaglandin E2 (PGE2) is one of the main catabolic factors involved in OA. Its synthesis is the result of cyclooxygenase (COX) and prostaglandin E synthase (PGES) activities wher...

Subject

Mechanosensitive channels

Prostaglandin E2

Cartilage

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