The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model

Bézard, Erwan; Y. Pioli, Elsa; Li, Qin; Girard, Françoise; Mutel, Vincent; Keywood, Charlotte; Tison, François; Rascol, Olivier; Poli, Sonia

doi:10.1002/mds.25920

Public

The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model

Published in Movement Disorders • May 27, 2014

Authors:

Erwan Bézard

Elsa Y. Pioli

Qin Li

Abstract

BACKGROUND: Blocking metabotropic glutamate receptor type 5 (mGluR5) has been proposed as a target for levodopa-induced dyskinesias (LID) in Parkinson's disease (PD). We assessed the effect on LID of dipraglurant, a potent selective mGluR5 receptor negative allosteric modulator in the gold-standard ...

Subject

Macaque

MPTP

Metabotropic glutamate receptor 5

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