The histone deacetylase inhibitor sodium butyrate decreases excessive ethanol intake in dependent animals

Simon‐O'Brien, Emmanuelle; Alaux‐Cantin, Stéphanie; Warnault, Vincent; Buttolo, Romain; Naassïla, Mickaël; Vilpoux, Catherine

doi:10.1111/adb.12161

Public

The histone deacetylase inhibitor sodium butyrate decreases excessive ethanol intake in dependent animals

Published in Addiction Biology • Jul 8, 2014

Authors:

Emmanuelle Simon‐O'Brien

Stéphanie Alaux‐Cantin

Vincent Warnault

Abstract

Converging evidence indicates that epigenetic mechanisms are involved in drug addiction, and that enzymes involved in chromatin remodeling may represent interesting targets in addiction treatment. No study has addressed whether histone deacetylase (HDAC) inhibitors (HDACi) can reduce excessive ethan...

Subject

Sodium butyrate

Histone deacetylase

Ethanol

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