Programmed Death (PD)-1:PD-Ligand 1/PD-Ligand 2 Pathway Inhibits T Cell Effector Functions during Human Tuberculosis

O. Jurado, Javier; B. Alvarez, Ivana; Pasquinelli, Virginia; Martínez, Gustavo; Florencia Quiroga, María; Abbate, Eduardo; Musella, Rosa; Chuluyán, Eduardo; García, Verónica

doi:10.4049/jimmunol.181.1.116

Public

Programmed Death (PD)-1:PD-Ligand 1/PD-Ligand 2 Pathway Inhibits T Cell Effector Functions during Human Tuberculosis

Published in The Journal of Immunology • Jul 1, 2008

Authors:

Javier O. Jurado

Ivana B. Alvarez

Virginia Pasquinelli

Abstract

Protective immunity against Mycobacterium tuberculosis requires the generation of cell-mediated immunity. We investigated the expression and role of programmed death 1 (PD-1) and its ligands, molecules known to modulate T cell activation, in the regulation of IFN-gamma production and lytic degranula...

Subject

T cell

Effector

Degranulation

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