Thiopurine methyl-transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine-treated inflammatory bowel disease patients

González‐Lama, Yago; Bermejo, Fernando; López–Sanromán, Antonio; García–Sánchez, Valle; Esteve, María; Luis Cabriada, José; G. McNicholl, Adrián; Pajares, Ramón; Casellas, Francesc; Merino, Olga; Carpio, Daniel; Isabel Vera-Muñoz, María; Muñoz, Carmen; Calvo, Marta; Benito-Manzanaro, Lucía; Bujanda, Luís; García-Fernández, F.; Ricart, Elena; Ginard, Daniel; Velasco, María; Carneros, J.A.; Manceñido, Noemí; Calvo, Marta; Algaba, A.; Froilan, C.; Cara, C.; Luís Mate, José; de Abreu, Letícia; P. Gisbert, Javier; behalf of “Grupo Español de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa (GETECCU)”, on

doi:10.1111/j.1365-2036.2011.04756.x

Public

Thiopurine methyl-transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine-treated inflammatory bowel disease patients

Published in Alimentary Pharmacology & Therapeutics • Jul 3, 2011

Authors:

Yago González‐Lama

Fernando Bermejo

Antonio López–Sanromán

Abstract

BACKGROUND: Low thiopurine-methyl-transferase (TPMT) activity and high 6-thioguanine-nucleotide (6TGN) concentrations have been linked to therapeutic success in inflammatory bowel disease patients treated with thiopurines; however, this has not been implemented in clinical practice. AIM: To identify...

Subject

Thiopurine methyltransferase

Azathioprine

Medicine

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