Molecular mechanism for duplication 17p11.2— the homologous recombination reciprocal of the Smith-Magenis microdeletion

Potocki, Lorraine; Chen, Ken-Shiung; Sup Park, Sung; E. Osterholm, Doreen; Withers, Marjorie; Kimonis, Virginia; Summers, Anne; S. Meschino, Wendy; Anyane‐Yeboa, Kwame; D. Kashork, Catherine; G. Shaffer, Lisa; R. Lupski, James

doi:10.1038/71743

Public

Molecular mechanism for duplication 17p11.2— the homologous recombination reciprocal of the Smith-Magenis microdeletion

Published in Nature Genetics • Jan 1, 2000

Authors:

Lorraine Potocki

Ken-Shiung Chen

Sung Sup Park

Abstract

Recombination between repeated sequences at various loci of the human genome are known to give rise to DNA rearrangements associated with many genetic disorders. Perhaps the most extensively characterized genomic region prone to rearrangement is 17p12, which is associated with the peripheral neuropa...

Subject

Gene duplication

Non-allelic homologous recombination

Biology

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