Association of µ-opioid receptor (OPRM1) gene polymorphism with response to naltrexone in alcohol dependence: a systematic review and meta-analysis.

Chamorro, Antonio-Javier; Marcos, Miguel; Mirón-Canelo, José-Antonio; Pastor, Isabel; González-Sarmiento, Rogelio; Laso, Francisco-Javier

doi:10.1111/j.1369-1600.2012.00442.x

Public

Association of µ-opioid receptor (OPRM1) gene polymorphism with response to naltrexone in alcohol dependence: a systematic review and meta-analysis.

Shared by NobleBlocks on May 1, 2012 • 12:00 AM UTC

Authors:

Antonio-Javier Chamorro

Miguel Marcos

José-Antonio Mirón-Canelo

Abstract

Previous studies have suggested that the effect of naltrexone in patients with alcohol dependence may be moderated by genetic factors. In particular, the possession of the G allele of the A118G polymorphism of the µ-opioid receptor gene (OPRM1) has been associated with a better response to naltrexon...

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