Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: the interplay of clonal anergy and immune regulation.

SA, Quezada; K, Bennett; BR, Blazar; AY, Rudensky; S, Sakaguchi; RJ, Noelle

doi:10.4049/jimmunol.175.2.771

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Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: the interplay of clonal anergy and immune regulation.

Shared by NobleBlocks on Jul 1, 2005 • 12:00 AM UTC

Authors:

Quezada SA

Bennett K

Blazar BR

Abstract

Although it has been shown that CD4(+)CD25(+) regulatory T cells (T(reg)) contribute to long-term graft acceptance, their impact on the effector compartment and the mechanism by which they exert suppression in vivo remain unresolved. Using a CD4(+) TCR transgenic model for graft tolerance, we have u...

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