ORIGINAL ARTICLE: Antiphospholipid Antibodies Induce a Pro‐Inflammatory Response in First Trimester Trophoblast Via the TLR4/MyD88 Pathway

J. Mulla, Melissa; J. Brosens, Jan; Chamley, Larry; Giles, Ian; Pericleous, Charis; Rahman, Anisur; K. Joyce, Shawna; Panda, Britta; J. Paidas, Michael; M. Abrahams, Vikki

doi:10.1111/j.1600-0897.2009.00717.x

Public

ORIGINAL ARTICLE: Antiphospholipid Antibodies Induce a Pro‐Inflammatory Response in First Trimester Trophoblast Via the TLR4/MyD88 Pathway

Published in American Journal of Reproductive Immunology • Jul 9, 2009

Authors:

Melissa J. Mulla

Jan J. Brosens

Larry Chamley

Abstract

PROBLEM: Women with antiphospholipid antibodies (aPL) are at risk for recurrent miscarriage, pre-eclampsia, and pre-term labor. aPL target the placenta directly by binding to beta(2)-glycoprotein I (beta(2)GPI) expressed on the surface of trophoblast cells. The objective of this study was to determi...

Subject

Trophoblast

Autocrine signalling

Antibody

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