ORIGINAL ARTICLE: Antiphospholipid Antibodies Induce a Pro‐Inflammatory Response in First Trimester Trophoblast Via the TLR4/MyD88 Pathway

J. Mulla, Melissa; J. Brosens, Jan; W. Chamley, Larry; Giles, Ian; Pericleous, Charis; Rahman, Anisur; K. Joyce, Shawna; Panda, Britta; J. Paidas, Michael; M. Abrahams, Vikki

doi:10.1111/j.1600-0897.2009.00717.x

Public

ORIGINAL ARTICLE: Antiphospholipid Antibodies Induce a Pro‐Inflammatory Response in First Trimester Trophoblast Via the TLR4/MyD88 Pathway

Shared by NobleBlocks on Jul 9, 2009 • 12:00 AM UTC

Authors:

Melissa J. Mulla

Jan J. Brosens

Larry W. Chamley

Abstract

Problem Women with antiphospholipid antibodies (aPL) are at risk for recurrent miscarriage, pre‐eclampsia, and pre‐term labor. aPL target the placenta directly by binding to beta 2 ‐glycoprotein I (β 2 GPI) expressed on the surface of trophoblast cells. The objective of this study was to determine t...

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