Established Human Papillomavirus Type 16-Expressing Tumors Are Effectively Eradicated Following Vaccination with Long Peptides

Zwaveling, Sander; C. Ferreira Mota, Sandra; Nouta, Jan; E. Johnson, Mark; B. Lipford, Grayson; Offringa, Rienk; H. van der Burg, Sjoerd; J.M. Melief, Cornelis

doi:10.4049/jimmunol.169.1.350

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Established Human Papillomavirus Type 16-Expressing Tumors Are Effectively Eradicated Following Vaccination with Long Peptides

Published in The Journal of Immunology • Jul 1, 2002

Authors:

Sander Zwaveling

Sandra C. Ferreira Mota

Jan Nouta

Abstract

Peptide-based vaccines aimed at the induction of effective T cell responses against established cancers have so far only met with limited clinical success and clearly need to be improved. In a preclinical model of human papillomavirus (HPV)16-induced cervical cancer we show that prime-boost vaccinat...

Subject

Human papillomavirus

Vaccination

Virology

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