The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction

Sudo, Nobuyuki; Sawamura, S.; Tanaka, Kazuo; Aiba, Y.; Kubo, Chiharu; Koga, Yuichi

doi:10.4049/jimmunol.159.4.1739

Public

The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction

Published in The Journal of Immunology • Aug 1, 1997

Authors:

Nobuyuki Sudo

S. Sawamura

Kazuo Tanaka

Abstract

The role of intestinal bacterial flora in oral tolerance induction to the IgE response was investigated using germfree (GF) mice. When GF mice were orally administered 20 mg of OVA as tolerogen before a systemic challenge with OVA, the Th1-mediated responses, such as the production of IgG2a and IFN-...

Subject

Biology

Immune system

Immunology

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