Cutting Edge: The Phosphoinositide 3-Kinase p110δ Is Critical for the Function of CD4+CD25+Foxp3+ Regulatory T Cells

T. Patton, Daniel; A. Garden, Oliver; Pearce, Wayne; E. Clough, Louise; R Monk, Clare; Leung, Eva; C. Rowan, Wendy; Sancho, Sara; S. K. Walker, Lucy; Vanhaesebroeck, Bart; Okkenhaug, Klaus

doi:10.4049/jimmunol.177.10.6598

Public

Cutting Edge: The Phosphoinositide 3-Kinase p110δ Is Critical for the Function of CD4+CD25+Foxp3+ Regulatory T Cells

Published in The Journal of Immunology • Nov 1, 2006

Authors:

Daniel T. Patton

Oliver A. Garden

Wayne Pearce

Abstract

CD4+CD25+Foxp3+ regulatory T cells (Tregs) contribute to the maintenance of peripheral tolerance by inhibiting the expansion and function of conventional T cells. Treg development and homeostasis are regulated by the Ag receptor, costimulatory receptors such as CD28 and CTLA-4, and cytokines such as...

Subject

FOXP3

IL-2 receptor

Cell biology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!