Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone.

L. McCarthy, Thomas; Canalis, Ernesto

doi:10.1016/s0021-9258(18)61587-x

Public

Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone.

Published in Journal of Biological Chemistry • Feb 1, 1987

Authors:

Thomas L. McCarthy

Ernesto Canalis

Abstract

Transforming growth factor beta (TGF beta) stimulates cell replication in fetal rat calvariae, and studies with isolated bone cells suggest that the primary mitogenically responsive cell is of the osteoblast lineage. The effect of TGF beta on bone cell replication is biphasic and depends on both the...

Subject

Osteoblast

Regulator

Cell biology

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