Cutting Edge: Lipoxins Rapidly Stimulate Nonphlogistic Phagocytosis of Apoptotic Neutrophils by Monocyte-Derived Macrophages

Godson, Catherine; Mitchell, Siobhán; Harvey, Killeen; A. Petasis, Nicos; Hogg, Nancy; R. Brady, Hugh

doi:10.4049/jimmunol.164.4.1663

Public

Cutting Edge: Lipoxins Rapidly Stimulate Nonphlogistic Phagocytosis of Apoptotic Neutrophils by Monocyte-Derived Macrophages

Published in The Journal of Immunology • Feb 1, 2000

Authors:

Catherine Godson

Siobhán Mitchell

Killeen Harvey

Abstract

Lipoxins (LX) are lipoxygenase-derived eicosanoids generated during inflammation. LX inhibit polymorphonuclear neutrophil (PMN) chemotaxis and adhesion and are putative braking signals for PMN-mediated tissue injury. In this study, we report that LXA4 promotes another important step in the resolutio...

Subject

Phagocytosis

Chemotaxis

Inflammation

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