The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis

Logan Susan, M.; Valdez, Patricia; Wu, Jianfeng; Jung, Kenneth; Zhong, Fiona; M. Hall, Linda; Kasman, Ian; Winer, Jane; Modrušan, Zora; M. Danilenko, Dimitry; Ouyang, Wenjun

doi:10.4049/jimmunol.178.4.2229

Public

The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis

Published in The Journal of Immunology • Feb 1, 2007

Authors:

M. Logan Susan

Patricia Valdez

Jianfeng Wu

Abstract

IL-19, IL-20, IL-22, IL-24, and IL-26 are members of the IL-10 family of cytokines that have been shown to be up-regulated in psoriatic skin. Contrary to IL-10, these cytokines signal using receptor complex R1 subunits that are preferentially expressed on cells of epithelial origin; thus, we hencefo...

Subject

Interleukin 20

Biology

Epidermis (zoology)

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