SB 203580 Inhibits p38 Mitogen-Activated Protein Kinase, Nitric Oxide Production, and Inducible Nitric Oxide Synthase in Bovine Cartilage-Derived Chondrocytes

M. Badger, Alison; N. Cook, Michael; W. Lark, Michael; Newman‐Tarr, Tonie; A. Swift, Barbara; H. Nelson, Allen; C. Barone, Frank; Kumar, Sanjay

doi:10.4049/jimmunol.161.1.467

Public

SB 203580 Inhibits p38 Mitogen-Activated Protein Kinase, Nitric Oxide Production, and Inducible Nitric Oxide Synthase in Bovine Cartilage-Derived Chondrocytes

Published in The Journal of Immunology • Jul 1, 1998

Authors:

Alison M. Badger

Michael N. Cook

Michael W. Lark

Abstract

Nitric oxide (NO) is implicated in a number of inflammatory processes and is an important mediator in animal models of rheumatoid arthritis and in in vitro models of cartilage degradation. The pyridinyl imidazole SB 203580 inhibits p38 mitogen-activated protein (MAP) kinase in vitro, blocks proinfla...

Subject

Nitric oxide synthase

Chondrocyte

Nitric oxide

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