The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

GTEx Consortium, The; G. Ardlie, Kristin; S. Deluca, David; V. Segrè, Ayellet; J. Sullivan, Timothy; R. Young, Taylor; T. Gelfand, Ellen; A. Trowbridge, Casandra; B. Maller, Julian; Tukiainen, Taru; Lek, Monkol; D. Ward, Lucas; Kheradpour, Pouya; Iriarte, Benjamin; Meng, Yan; D. Palmer, Cameron; Esko, Tõnu; Winckler, Wendy; N. Hirschhorn, Joel; Kellis, Manolis; G. MacArthur, Daniel; Getz, Gad; A. Shabalin, Andrey; Li, Gen; Zhou, Yi-Hui; B. Nobel, Andrew; Rusyn, Ivan; A. Wright, Fred; Lappalainen, Tuuli; G. Ferreira, Pedro; Ongen, Halit; A. Rivas, Manuel; Battle, Alexis; Mostafavi, Sara; Monlong, Jean; Sammeth, Michael; Mele, Marta; Reverter, Ferran; M. Goldmann, Jakob; Koller, Daphne; Guigó, Roderic; I. McCarthy, Mark; T. Dermitzakis, Emmanouil; R. Gamazon, Eric; Kyung Im, Hae; Konkashbaev, Anuar; L. Nicolae, Dan; J. Cox, Nancy; Flutre, Timothée; Wen, Xiaoquan; Stephens, Matthew; K. Pritchard, Jonathan; Tu, Zhidong; Zhang, Bin; Huang, Tao; Long, Quan; Lin, Luan; Yang, Jialiang; Zhu, Jun; Liu, Jun; Brown, Amanda; Mestichelli, Bernadette; Tidwell, Denee; Lo, Edmund; Salvatore, Mike; Shad, Saboor; A. Thomas, Jeffrey; T. Lonsdale, John; T. Moser, Michael; M. Gillard, Bryan; Karasik, Ellen; Ramsey, Kimberly; Choi, Christopher; A. Foster, Barbara; Syron, John; Fleming, Johnell; Magazine, Harold; Hasz, Rick; D. Walters, Gary; P. Bridge, Jason; Miklos, Mark; Sullivan, Susan; K. Barker, Laura; M. Traino, Heather; Mosavel, Maghboeba; A. Siminoff, Laura; R. Valley, Dana; C. Rohrer, Daniel; D. Jewell, Scott; A. Branton, Philip; H. Sobin, Leslie; Barcus, Mary; Qi, Liqun; McLean, Jeffrey; Hariharan, Pushpa; Sung Um, Ki; Wu, Shenpei; Tabor, David; Shive, Charles; M. Smith, Anna; A. Buia, Stephen; H. Undale, Anita; L. Robinson, Karna; Roche, Nancy; M. Valentino, Kimberly; Britton, Angela; Burges, Robin; Bradbury, Debra; W. Hambright, Kenneth; Seleski, John; E. Korzeniewski, Greg; Erickson, Kenyon; Marcus, Yvonne; Tejada, Jorge; Taherian, Mehran; Lu, Chunrong; Basile, Margaret; C. Mash, Deborah; Volpi, Simona; P. Struewing, Jeffery; F. Temple, Gary; Boyer, Joy; Colantuoni, Deborah; Little, Roger; Koester, Susan; J. Carithers, Latarsha; M. Moore, Helen; Guan, Ping; Compton, Carolyn; J. Sawyer, Sherilyn; P. Demchok, Joanne; B. Vaught, Jimmie; A. Rabiner, Chana; C. Lockhart, Nicole; G. Ardlie, Kristin; Getz, Gad; A. Wright, Fred; Kellis, Manolis; Volpi, Simona; T. Dermitzakis, Emmanouil

doi:10.1126/science.1262110

Public

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

Shared by NobleBlocks on May 8, 2015 • 12:00 AM UTC

Authors:

The GTEx Consortium

Kristin G. Ardlie

David S. Deluca

Abstract

Expression, genetic variation, and tissues Human genomes show extensive genetic variation across individuals, but we have only just started documenting the effects of this variation on the regulation of gene expression. Furthermore, only a few tissues have been examined per genetic variant. In order...

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