The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

G. Ardlie, Kristin; S. DeLuca, David; V. Segrè, Ayellet; J. Sullivan, Timothy; Young, Taylor; Gelfand, Ellen; A. Trowbridge, Casandra; Maller, Julian; Tukiainen, Taru; Lek, Monkol; D. Ward, Lucas; Kheradpour, Pouya; Iriarte, Benjamin; Meng, Yan; D. Palmer, Cameron; Esko, Tõnu; Winckler, Wendy; N. Hirschhorn, Joel; Kellis, Manolis; G. MacArthur, Daniel; Getz, Gad; A. Shabalin, Andrey; Li, Gen; Zhou, Yi‐Hui; B. Nobel, Andrew; Rusyn, Ivan; A. Wright, Fred; Lappalainen, Tuuli; G. Ferreira, Pedro; Ongen, Halit; A. Rivas, Manuel; Battle, Alexis; Mostafavi, Sara; Monlong, Jean; Sammeth, Michael; Melé, Marta; Reverter, Ferrán; M. Goldmann, Jakob; Koller, Daphne; Guigó, Roderic; I. McCarthy, Mark; T. Dermitzakis, Emmanouil; R. Gamazon, Eric; Kyung Im, Hae; Konkashbaev, Anuar; L. Nicolae, Dan; J. Cox, Nancy; Flutre, Timothée; Wen, Xiaoquan; Stephens, Matthew; K. Pritchard, Jonathan; Tu, Zhidong; Zhang, Bin; Huang, Tao; Long, Quan; Lin, Luan; Yang, Jialiang; Zhu, Jun; Liu, Jun; Brown, Amanda; Mestichelli, Bernadette; Tidwell, Denee; Lo, Edmund; Salvatore, Mike; Shad, Saboor; A. Thomas, Jeffrey; T. Lonsdale, John; T. Moser, Michael; M. Gillard, Bryan; Karasik, Ellen; Ramsey, Kimberly; Choi, Christopher; A. Foster, Barbara; Syron, John; Fleming, Johnell; I. Magazine, Harold; Hasz, Rick; Walters, Gary; Bridge, Jason; Miklos, Mark; Sullivan, Susan; K. Barker, Laura; M. Traino, Heather; Mosavel, Maghboeba; A. Siminoff, Laura; R. Valley, Dana; C. Rohrer, Daniel; D. Jewell, Scott; A. Branton, Philip; H. Sobin, Leslie; E. Barcus, Mary; Qi, Liqun; A. McLean, Jeffrey; Hariharan, Pushpa; Sung Um, Ki; Wu, Shenpei; E. Tabor, David; Shive, Charles; M. Smith, Anna; A. Buia, Stephen; H. Undale, Anita; Robinson, Karna; Roche, Nancy; M. Valentino, Kimberly; Britton, Angela; Burges, Robin; Bradbury, Debra; W. Hambright, Kenneth; Seleski, John; E. Korzeniewski, Greg; Erickson, Kenyon; Marcus, Yvonne; Tejada, Jorge; Taherian, Mehran; Lu, Chunrong; J. Basile, Margaret; C. Mash, Deborah; Volpi, Simona; P. Struewing, Jeffery; F. Temple, Gary; T Boyer, Joy; Colantuoni, Deborah; Little, Roger; E. Koester, Susan; J. Carithers, Latarsha; M. Moore, Helen; Guan, Ping; C. Compton, Carolyn; J. Sawyer, Sherilyn; P. Demchok, Joanne; B. Vaught, Jimmie; A. Rabiner, Chana; C. Lockhart, Nicole; G. Ardlie, Kristin; Getz, Gad; A. Wright, Fred; Kellis, Manolis; Volpi, Simona; T. Dermitzakis, Emmanouil

doi:10.1126/science.1262110

Public

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

Published in Science • May 7, 2015

Authors:

Kristin G. Ardlie

David S. DeLuca

Ayellet V. Segrè

Abstract

Understanding the functional consequences of genetic variation, and how it affects complex human disease and quantitative traits, remains a critical challenge for biomedicine. We present an analysis of RNA sequencing data from 1641 samples across 43 tissues from 175 individuals, generated as part of...

Subject

Biology

Genetic variation

Gene expression

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