Up-Regulation of Macrophage Inflammatory Protein-3α/CCL20 and CC Chemokine Receptor 6 in Psoriasis

Homey, Bernhard; Dieu‐Nosjean, Marie‐Caroline; Wiesenborn, Andrea; Massacrier, Catherine; Pin, Jean‐Jacques; R. Oldham, Elizabeth; Catron, Daniel; E. Buchanan, Matthew; Müller, Anja; de Waal Malefyt, René; Deng, Glenn; Orozco, Rocio; Ruzicka, Thomas; Lehmann, Percy; Lebecque, Serge; Caux, Christophe; Zlotnik, Albert

doi:10.4049/jimmunol.164.12.6621

Public

Up-Regulation of Macrophage Inflammatory Protein-3α/CCL20 and CC Chemokine Receptor 6 in Psoriasis

Published in The Journal of Immunology • Jun 1, 2000

Authors:

Bernhard Homey

Marie‐Caroline Dieu‐Nosjean

Andrea Wiesenborn

Abstract

Autoimmunity plays a key role in the immunopathogenesis of psoriasis; however, little is known about the recruitment of pathogenic cells to skin lesions. We report here that the CC chemokine, macrophage inflammatory protein-3 alpha, recently renamed CCL20, and its receptor CCR6 are markedly up-regul...

Subject

CCL20

C-C chemokine receptor type 6

Chemokine

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