Specialized Membrane Domains for Water Transport in Glial Cells: High-Resolution Immunogold Cytochemistry of Aquaporin-4 in Rat Brain

Nielsen, Søren; A. Nagelhus, Erlend; Amiry‐Moghaddam, Mahmood; W. Bourque, Charles; Agre, Peter; Petter Ottersen, Ole

doi:10.1523/jneurosci.17-01-00171.1997

Public

Specialized Membrane Domains for Water Transport in Glial Cells: High-Resolution Immunogold Cytochemistry of Aquaporin-4 in Rat Brain

Published in Journal of Neuroscience • Jan 1, 1997

Authors:

Søren Nielsen

Erlend A. Nagelhus

Mahmood Amiry‐Moghaddam

Abstract

Membrane water transport is critically involved in brain volume homeostasis and in the pathogenesis of brain edema. The cDNA encoding aquaporin-4 (AQP4) water channel protein was recently isolated from rat brain. We used immunocytochemistry and high-resolution immunogold electron microscopy to ident...

Subject

Immunogold labelling

Ependymal Cell

Aquaporin 4

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