Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Rising TAK-438 (Vonoprazan) Doses in Healthy Male Japanese/non-Japanese Subjects

Sakurai, Yuuichi; Nishimura, Akira; Kennedy, Gale; G. Hibberd, Mark; O. Jenkins, Richard; Okamoto, Hiroyuki; Yoneyama, Tomoki; Jenkins, Helen; Ashida, Kiyoshi; Irie, Shin; Täubel, Jörg

doi:10.1038/ctg.2015.18

Public

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Rising TAK-438 (Vonoprazan) Doses in Healthy Male Japanese/non-Japanese Subjects

Published in Clinical and Translational Gastroenterology • Jun 1, 2015

Authors:

Yuuichi Sakurai

Akira Nishimura

Gale Kennedy

Abstract

OBJECTIVES: To evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics of TAK-438 (vonoprazan, a potassium-competitive acid blocker) in healthy male subjects. METHODS: In two phase I, randomized, double-blind, placebo-controlled, single rising-dose studies, healthy male subjects (Japan...

Subject

Tolerability

Pharmacokinetics

Medicine

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