Integrated pharmacokinetic, pharmacodynamic and immunogenicity profiling of an anti-CCL21 monoclonal antibody in cynomolgus monkeys

Dudal, Sherri; Subramanian, Kalyanasundaram; Flandre, Thierry; Law, W.T.; J. Lowe, Philip; Skerjanec, Andrej; Genin, J-C; Duval, M.; Piequet, Aline; Cordier, A.; Járai, Gábor; Van Heeke, Gino; Taplin, Sarah; Krantz, Carsten; Jones, Stewart; Warren, AP; Brennan, FR; Sims, J.C.; Lloyd, Peter

doi:10.1080/19420862.2015.1060384

Public

Integrated pharmacokinetic, pharmacodynamic and immunogenicity profiling of an anti-CCL21 monoclonal antibody in cynomolgus monkeys

Published in mAbs • Jul 31, 2015

Authors:

Sherri Dudal

Kalyanasundaram Subramanian

Thierry Flandre

Abstract

QBP359 is an IgG1 human monoclonal antibody that binds with high affinity to human CCL21, a chemokine hypothesized to play a role in inflammatory disease conditions through activation of resident CCR7-expressing fibroblasts/myofibroblasts. The pharmacokinetics (PK) and pharmacodynamics (PD) of QBP35...

Subject

Monoclonal antibody

Immunogenicity

Pharmacokinetics

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