<scp>CD</scp>161<sup>++</sup><scp>CD</scp>8<sup>+</sup><scp>T</scp> cells, including the <scp>MAIT</scp> cell subset, are specifically activated by <scp>IL</scp>‐12+<scp>IL</scp>‐18 in a <scp>TCR</scp>‐independent manner

E. Ussher, James; Bilton, Matthew; Attwod, Emma; Shadwell, Jonathan; Richardson, Rachel; de Lara, Catherine; Mettke, Elisabeth; Kurioka, Ayako; H. Hansen, Ted; Klenerman, Paul; B. Willberg, Christian

doi:10.1002/eji.201343509

Public

CD161++CD8+T cells, including the MAIT cell subset, are specifically activated by IL‐12+IL‐18 in a TCR‐independent manner

Published in European Journal of Immunology • Sep 11, 2013

Authors:

James E. Ussher

Matthew Bilton

Emma Attwod

Abstract

CD161(++) CD8(+) T cells represent a novel subset that is dominated in adult peripheral blood by mucosal-associated invariant T (MAIT) cells, as defined by the expression of a variable-α chain 7.2 (Vα7.2)-Jα33 TCR, and IL-18Rα. Stimulation with IL-18+IL-12 is known to induce IFN-γ by both NK cells a...

Subject

Population

Biology

CD8

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!