CpG DNA Activates Survival in Murine Macrophages through TLR9 and the Phosphatidylinositol 3-Kinase-Akt Pathway

P. Sester, David; Brion, Kristian; Trieu, Angela; S. Goodridge, Helen; L. Roberts, Tara; A. Dunn, Jasmyn; Hume, David; J. Stacey, Katryn; J. Sweet, Matthew

doi:10.4049/jimmunol.177.7.4473

Public

CpG DNA Activates Survival in Murine Macrophages through TLR9 and the Phosphatidylinositol 3-Kinase-Akt Pathway

Published in The Journal of Immunology • Oct 1, 2006

Authors:

David P. Sester

Kristian Brion

Angela Trieu

Abstract

Bacterial CpG-containing (CpG) DNA promotes survival of murine macrophages and triggers production of proinflammatory mediators. The CpG DNA-induced inflammatory response is mediated via TLR9, whereas a recent study reported that activation of the Akt prosurvival pathway occurs via DNA-dependent pro...

Subject

TLR9

Protein kinase B

CpG site

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!