Oxidative Damage Is the Earliest Event in Alzheimer Disease

Nunomura, Akihiko; Perry, George; Aliev, Gjumrakch; Hirai, Keisuke; Takeda, Atsushi; K. Balraj, Elizabeth; K. Jones, Paul; Ghanbari, Hossein; Wataya, Takafumi; Shimohama, Shun; Chiba, Shigeru; Atwood, Craig; B. Petersen, Robert; A. Smith, Mark

doi:10.1093/jnen/60.8.759

Public

Oxidative Damage Is the Earliest Event in Alzheimer Disease

Published in Journal of Neuropathology & Experimental Neurology • Aug 1, 2001

Authors:

Akihiko Nunomura

George Perry

Gjumrakch Aliev

Abstract

Recently, we demonstrated a significant increase of an oxidized nucleoside derived from RNA, 8-hydroxyguanosine (8OHG), and an oxidized amino acid, nitrotyrosine in vulnerable neurons of patients with Alzheimer disease (AD). To determine whether oxidative damage is an early- or end-stage event in th...

Subject

Oxidative stress

Neurodegeneration

Nitrotyrosine

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