Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

van Steen, Eric; M. Terry, Benjamin; J. Rivera, Enrique; Cannon, Jennifer; R. Neely, Thomas; Tavares, Rose; Xu, Xiangdong; R. Wands, Jack; M. de la Monte, Suzanne

doi:10.3233/jad-2005-7107

Public

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

Published in Journal of Alzheimer s Disease • Mar 3, 2005

Authors:

Eric van Steen

Benjamin M. Terry

Enrique J. Rivera

Abstract

The neurodegeneration that occurs in sporadic Alzheimer's disease (AD) is consistently associated with a number of characteristic histopathological, molecular, and biochemical abnormalities, including cell loss, abundant neurofibrillary tangles and dystrophic neurites, amyloid-beta deposits, increas...

Subject

Insulin receptor

Endocrinology

Internal medicine

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