BRCA2 Germline Mutations in Familial Pancreatic Carcinoma

A. Hahn, Stephan; Greenhalf, B.; Ellis, I.; Sina‐Frey, Mercedes; Rieder, Harald; Korte, B.; Gerdes, Berthold; Kress, R.; Ziegler, Andreas; A. Raeburn, J.; Campra, Donata; Grützmann, Robert; Rehder, Helga; Rothmund, Μ.; Schmiegel, Wolff; P. Neoptolemos, John; K. Bartsch, Detlef

doi:10.1093/jnci/95.3.214

Public

BRCA2 Germline Mutations in Familial Pancreatic Carcinoma

Published in JNCI Journal of the National Cancer Institute • Feb 5, 2003

Authors:

Stephan A. Hahn

B. Greenhalf

I. Ellis

Abstract

BACKGROUND: Although as many as 10% of pancreatic cancer cases may have an inherited component, familial pancreatic cancer has not been linked to defects in any specific gene. Some studies have shown that families with germline mutations in the breast cancer susceptibility gene BRCA2 have an increas...

Subject

BRCA2 Protein

Frameshift mutation

Germline mutation

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