T cells expressing a LMP1-specific chimeric antigen receptor mediate antitumor effects against LMP1-positive nasopharyngeal carcinoma cells in vitro and in vivo

Xiaojun, Tang; Zhou, Yan; Li, Wenjie; Tang, Qi; Renjie, Chen; Zhu, Jin; Feng, Zhenqing

doi:10.7555/jbr.28.20140066

Public

T cells expressing a LMP1-specific chimeric antigen receptor mediate antitumor effects against LMP1-positive nasopharyngeal carcinoma cells in vitro and in vivo

Published in Journal of Biomedical Research • Jan 1, 2014

Authors:

Tang Xiaojun

Yan Zhou

Wenjie Li

Abstract

T cells modified with chimeric antigen receptor are an attractive strategy to treat Epstein-Barr virus (EBV) associated malignancies. The EBV latent membrane protein 1 (LMP1) is a 66-KD integral membrane protein encoded by EBV that consists of transmembrane-spanning loops. Previously, we have identi...

Subject

HeLa

Chimeric antigen receptor

Nasopharyngeal carcinoma

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