Inhibition of Antigen-Induced Eosinophilia and Late Phase Airway Hyperresponsiveness by an IL-5 Antisense Oligonucleotide in Mouse Models of Asthma

G. Karras, James; McGraw, Kathy; A. McKay, Robert; Cooper, Scott; Lerner, Dmitri; Lü, Tao; Walker, Christoph; M. Dean, Nicholas; P. Monia, Brett

doi:10.4049/jimmunol.164.10.5409

Public

Inhibition of Antigen-Induced Eosinophilia and Late Phase Airway Hyperresponsiveness by an IL-5 Antisense Oligonucleotide in Mouse Models of Asthma

Published in The Journal of Immunology • May 1, 2000

Authors:

James G. Karras

Kathy McGraw

Robert A. McKay

Abstract

Chronic airway eosinophilia is associated with allergic asthma and is mediated in part by secretion of IL-5 from allergen-specific Th2 lymphocytes. IL-5 is a known maturation and antiapoptotic factor for eosinophils and stimulates release of nascent eosinophils from bone marrow into the peripheral c...

Subject

Eosinophilia

Eosinophil

Immunology

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