Role for macrophage inflammatory protein (MIP)-1α and MIP-1β in the development of osteolytic lesions in multiple myeloma

Abe, Masahiro; Hiura, Kenji; Wilde, Javier; Moriyama, Keiji; Hashimoto, Toshihiro; Ozaki, Shuji; Wakatsuki, Shingo; Kosaka, Masaaki; Kido, Shinsuke; Inoue, Daisuke; Matsumoto, Toshio

doi:10.1182/blood.v100.6.2195

Public

Role for macrophage inflammatory protein (MIP)-1α and MIP-1β in the development of osteolytic lesions in multiple myeloma

Published in Blood • Sep 15, 2002

Authors:

Masahiro Abe

Kenji Hiura

Javier Wilde

Abstract

Multiple myeloma (MM) cells cause devastating bone destruction by activating osteoclasts in the bone marrow milieu. However, the mechanism of enhanced bone resorption in patients with myeloma is poorly understood. In the present study, we investigated a role of C-C chemokines, macrophage inflammator...

Subject

Stromal cell

Osteoclast

Bone resorption

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