Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro.

Kuber Sampath, T.; C. Maliakal, James; V. Hauschka, Peter; K. Jones, William; Sasak, Halina; F Tucker, R; White, Kerry; E. Coughlin, John; Tucker, Marjorie; Pang, Ruo-dan

doi:10.1016/s0021-9258(19)88709-4

Public

Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro.

Published in Journal of Biological Chemistry • Oct 1, 1992

Authors:

T. Kuber Sampath

James C. Maliakal

Peter V. Hauschka

Abstract

We reported previously that a 32-36-kDa osteogenic protein purified from bovine bone matrix is composed of dimers of two members of the transforming growth factor (TGF)-beta superfamily: the bovine equivalent of human osteogenic protein-1 (OP-1) and bone morphogenetic protein-2a, BMP-2a (BMP-2). In ...

Subject

Osteocalcin

Osteoblast

Alkaline phosphatase

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