IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary <i>Mycobacterium bovis</i> Bacille Calmette-Guerin Infection

Umemura, Masayuki; Yahagi, Ayano; Hamada, Satoru; Dilara Begum, Mst.; Watanabe, Hisami; Kawakami, Kazuyoshi; Suda, Takashi; Sudo, Katsuko; Nakae, Susumu; Iwakura, Yoichiro; Matsuzaki, Goro

doi:10.4049/jimmunol.178.6.3786

Public

IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary Mycobacterium bovis Bacille Calmette-Guerin Infection

Published in The Journal of Immunology • Mar 1, 2007

Authors:

Masayuki Umemura

Ayano Yahagi

Satoru Hamada

Abstract

IL-17 is a cytokine that induces neutrophil-mediated inflammation, but its role in protective immunity against intracellular bacterial infection remains unclear. In the present study, we demonstrate that IL-17 is an important cytokine not only in the early neutrophil-mediated inflammatory response, ...

Subject

Mycobacterium bovis

Innate immune system

Immune system

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