L‐dopa increases α‐synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro

Schmitt, Ina; Kaut, Oliver; Khazneh, Hassan; deBoni, Laura; Ahmad, Ashar; Berg, Daniela; Klein, Christine; Fröhlich, Holger; Wüllner, Ullrich

doi:10.1002/mds.26319

Public

L‐dopa increases α‐synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro

Published in Movement Disorders • Jul 14, 2015

Authors:

Ina Schmitt

Oliver Kaut

Hassan Khazneh

Abstract

BACKGROUND: Increasing gene dosages of α-synuclein induce familial Parkinson's disease (PD); thus, the hypothesis has been put forward that regulation of gene expression, in particular altered α-synuclein gene methylation, might be associated with sporadic PD and could be used as a biological marker...

Subject

In vivo

In vitro

Parkinson's disease

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