L‐dopa increases α‐synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro

Schmitt, Ina; Kaut, Oliver; Khazneh, Hassan; deBoni, Laura; Ahmad, Ashar; Berg, Daniela; Klein, Christine; Fröhlich, Holger; Wüllner, Ullrich

doi:10.1002/mds.26319

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L‐dopa increases α‐synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro

Shared by NobleBlocks on Jul 14, 2015 • 12:00 AM UTC

Authors:

Ina Schmitt

Oliver Kaut

Hassan Khazneh

Abstract

Abstract Background Increasing gene dosages of α‐synuclein induce familial Parkinson's disease (PD); thus, the hypothesis has been put forward that regulation of gene expression, in particular altered α‐synuclein gene methylation, might be associated with sporadic PD and could be used as a biologica...

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