Paranodal Interactions Regulate Expression of Sodium Channel Subtypes and Provide a Diffusion Barrier for the Node of Ranvier

C. Rios, Jose; Rubin, Marina; St. Martin, Mary; T. Downey, Ryan; Einheber, Steven; Rosenbluth, Jack; Rock Levinson, S.; A. Bhat, Manzoor; L. Salzer, James

doi:10.1523/jneurosci.23-18-07001.2003

Public

Paranodal Interactions Regulate Expression of Sodium Channel Subtypes and Provide a Diffusion Barrier for the Node of Ranvier

Published in Journal of Neuroscience • Aug 6, 2003

Authors:

Jose C. Rios

Marina Rubin

Mary St. Martin

Abstract

The node of Ranvier is a distinct domain of myelinated axons that is highly enriched in sodium channels and is critical for impulse propagation. During development, the channel subtypes expressed at the node undergo a transition from Nav1.2 to Nav1.6. Specialized junctions that form between the para...

Subject

Node of Ranvier

Sodium channel

Axon

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