Paranodal interactions regulate expression of sodium channel subtypes and provide a diffusion barrier for the node of Ranvier.

JC, Rios; M, Rubin; Martin M, St; RT, Downey; S, Einheber; J, Rosenbluth; SR, Levinson; M, Bhat; JL, Salzer

doi:10.1523/jneurosci.23-18-07001.2003

Public

Paranodal interactions regulate expression of sodium channel subtypes and provide a diffusion barrier for the node of Ranvier.

Shared by NobleBlocks on Aug 1, 2003 • 12:00 AM UTC

Authors:

Rios JC

Rubin M

St Martin M

Abstract

The node of Ranvier is a distinct domain of myelinated axons that is highly enriched in sodium channels and is critical for impulse propagation. During development, the channel subtypes expressed at the node undergo a transition from Nav1.2 to Nav1.6. Specialized junctions that form between the para...

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