Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication.

Shen, Like; Wu, Lai‐Chu; Şanlıoğlu, Salih; Chen, Ruoyi; Mendoza, AnnaR.; W. Dangel, Andrew; C. Carroll, Michael; Zipf, W.B.; Yung Yu, C.

doi:10.1016/s0021-9258(17)37217-4

Public

Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication.

Published in Journal of Biological Chemistry • Mar 1, 1994

Authors:

Like Shen

Lai‐Chu Wu

Salih Şanlıoğlu

Abstract

The correlation of many HLA-associated autoimmune and genetic diseases with the polymorphic complement C4 genes may be attributed to the presence of disease susceptibility genes in the close proximity of C4. We have cloned and characterized a pair of partially duplicated genes, RP1 and RP2, located ...

Subject

C4A

Exon

Gene

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!