Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

Yoshida, Minoru; Kijima, Masako; Akita, Motomu; Beppu, Toru

doi:10.1016/s0021-9258(17)44885-x

Public

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

Published in Journal of Biological Chemistry • Oct 1, 1990

Authors:

Minoru Yoshida

Masako Kijima

Motomu Akita

Abstract

(R)-Trichostatin A (TSA) is a Streptomyces product which causes the induction of Friend cell differentiation and specific inhibition of the cell cycle of normal rat fibroblasts in the G1 and G2 phases at the very low concentrations. We found that TSA caused an accumulation of acetylated histone spec...

Subject

Trichostatin A

Histone deacetylase

Acetylation

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