Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors

Oscier, David; Gardiner, Anne; Mould, Sarah; Glide, Sharron; Davis, Zadie; Ibbotson, Rachel; Corcoran, Martin; M. Chapman, Robert; Thomas, Peter; A. Copplestone, J.; Orchard, Jenny; J. Hamblin, Terry

doi:10.1182/blood.v100.4.1177.h81602001177_1177_1184

Public

Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors

Published in Blood • Aug 15, 2002

Authors:

David Oscier

Anne Gardiner

Sarah Mould

Abstract

This study evaluates the prognostic significance of genetic abnormalities (detected at or shortly after presentation), clinical stage, lymphocyte morphology, CD38 expression, and IGVH gene status in 205 patients with chronic lymphocytic leukemia (B-CLL). Deletion of chromosome 11q23, absence of a de...

Subject

Biology

CD38

Chronic lymphocytic leukemia

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