IL-8 Directly Enhanced Endothelial Cell Survival, Proliferation, and Matrix Metalloproteinases Production and Regulated Angiogenesis

Li, Aihua; Dubey, Seema; L Varney, Michelle; J. Davé, Bhavana; K. Singh, Rakesh

doi:10.4049/jimmunol.170.6.3369

Public

IL-8 Directly Enhanced Endothelial Cell Survival, Proliferation, and Matrix Metalloproteinases Production and Regulated Angiogenesis

Published in The Journal of Immunology • Mar 1, 2003

Authors:

Aihua Li

Seema Dubey

Michelle L Varney

Abstract

IL-8, a member of the chemokine family, has been shown to play an important role in tumor growth, angiogenesis, and metastasis. The objective of this study was to determine the mechanism of IL-8-mediated angiogenesis. We examined the direct role of IL-8 in angiogenesis by examining IL-8 receptor exp...

Subject

Angiogenesis

Matrix metalloproteinase

Endothelial stem cell

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