Recombinant soluble human interleukin-5 (hIL-5) receptor molecules. Cross-linking and stoichiometry of binding to IL-5.

Devos, René; Guisez, Yves; Cornelis, Sigrid; Verhee, Annick; Van der Heyden, José; Manneberg, Michael; W Lahm, H; Fiers, Walter; Tavernier, Jan; Plaetinck, Geert

doi:10.1016/s0021-9258(18)53290-7

Public

Recombinant soluble human interleukin-5 (hIL-5) receptor molecules. Cross-linking and stoichiometry of binding to IL-5.

Published in Journal of Biological Chemistry • Mar 1, 1993

Authors:

René Devos

Yves Guisez

Sigrid Cornelis

Abstract

Recombinant soluble human interleukin-5 receptor alpha (shIL-5R alpha) has been expressed in COS-1 cells and in baculovirus-infected cells. The protein was purified from the supernatant by chromatography on concanavalin A-Sepharose, MonoQ, and a final gel filtration step. A chimeric fusion receptor ...

Subject

Recombinant DNA

Stoichiometry

Chemistry

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