Immunization of HLA Class I Transgenic Mice Identifies Autoantigenic Epitopes Eliciting Dominant Responses in Type 1 Diabetes Patients

Blancou, Philippe; Mallone, Roberto; Martinuzzi, Emanuela; Sévère, Sabine; Pogu, Sylvie; Novelli, Giulia; Bruno, Graziella; Charbonnel, B; Dolz, Manuel; Chaillous, Lucy; Van Endert, Peter; Bach, Jean‐Marie

doi:10.4049/jimmunol.178.11.7458

Public

Immunization of HLA Class I Transgenic Mice Identifies Autoantigenic Epitopes Eliciting Dominant Responses in Type 1 Diabetes Patients

Published in The Journal of Immunology • Jun 1, 2007

Authors:

Philippe Blancou

Roberto Mallone

Emanuela Martinuzzi

Abstract

Type 1 diabetes (T1D) results from the autoimmune destruction of pancreatic beta cells. CD8(+) T cells have recently been assigned a major role in beta cell injury. Consequently, the identification of autoreactive CD8(+) T cells in humans remains essential for development of therapeutic strategies a...

Subject

Epitope

Immunology

Biology

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