Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation.

H June, C; C. Fletcher, Mary; A Ledbetter, J; E. Samelson, Lawrence

doi:10.4049/jimmunol.144.5.1591

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Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation.

Published in The Journal of Immunology • Mar 1, 1990

Authors:

C H June

Mary C. Fletcher

J A Ledbetter

Abstract

Antiphosphotyrosine immunoblots were used to characterize tyrosine phosphorylated proteins after stimulation of the human TCR. Increased tyrosine phosphorylation was evident on at least 12 substrates within 2 min after ligation of the TCR with mAb. Analysis of the time course for increased tyrosine ...

Subject

Tyrosine phosphorylation

Phosphorylation

Biology

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