Notch-1 Up-Regulation and Signaling following Macrophage Activation Modulates Gene Expression Patterns Known to Affect Antigen-Presenting Capacity and Cytotoxic Activity

M. Monsalve, Eva; Ángel Sebastián Pérez, Miguel; Rubio, Antonio; José Ruiz‐Hidalgo, María; Baladrón, Victoriano; Javier Garcı́a-Ramı́rez, José; Carlos Gómez, Juan; Laborda, Jorge; José Guerra Palmero, María

doi:10.4049/jimmunol.176.9.5362

Public

Notch-1 Up-Regulation and Signaling following Macrophage Activation Modulates Gene Expression Patterns Known to Affect Antigen-Presenting Capacity and Cytotoxic Activity

Published in The Journal of Immunology • May 1, 2006

Authors:

Eva M. Monsalve

Miguel Ángel Sebastián Pérez

Antonio Rubio

Abstract

Notch signaling has been extensively implicated in cell-fate determination along the development of the immune system. However, a role for Notch signaling in fully differentiated immune cells has not been clearly defined. We have analyzed the expression of Notch protein family members during macroph...

Subject

Notch signaling pathway

Cell biology

Notch proteins

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