Cutting Edge: CD8+CD122+ Regulatory T Cells Produce IL-10 to Suppress IFN-γ Production and Proliferation of CD8+ T Cells

Tri Endharti, Agustina; Rifa, Muhaimin; Shi, Zhe; Fukuoka, Yukari; Nakahara, Yoshio; Kawamoto, Yoshiyuki; Takeda, Kozue; Isobe, Ken‐ichi; Suzuki, Haruhiko

doi:10.4049/jimmunol.175.11.7093

Public

Cutting Edge: CD8+CD122+ Regulatory T Cells Produce IL-10 to Suppress IFN-γ Production and Proliferation of CD8+ T Cells

Published in The Journal of Immunology • Dec 1, 2005

Authors:

Agustina Tri Endharti

Muhaimin Rifa

Zhe Shi

Abstract

We recently identified CD8+CD122+ regulatory T cells that directly control CD8+ and CD4+ cells without intervention of APCs. In this study, we investigated the effector mechanism of CD8+CD122+ regulatory T cells by using an in vitro regulation system. The profile of cytokine expression revealed that...

Subject

Cytotoxic T cell

CD8

Biology

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