Tumor Necrosis Factor α Induces a Metalloprotease-Disintegrin, ADAM8 (CD 156): Implications for Neuron–Glia Interactions during Neurodegeneration

Schlomann, Uwe; Rathke‐Hartlieb, Silvia; Yamamoto, Shunsuke; Jockusch, Harald; W. Bartsch, Jörg

doi:10.1523/jneurosci.20-21-07964.2000

Public

Tumor Necrosis Factor α Induces a Metalloprotease-Disintegrin, ADAM8 (CD 156): Implications for Neuron–Glia Interactions during Neurodegeneration

Published in Journal of Neuroscience • Nov 1, 2000

Authors:

Uwe Schlomann

Silvia Rathke‐Hartlieb

Shunsuke Yamamoto

Abstract

ADAM proteases, defined by extracellular disintegrin and metalloprotease domains, are involved in protein processing and cell-cell interactions. Using wobbler (WR) mutant mice, we investigated the role of ADAMs in neurodegeneration and reactive glia activation in the CNS. We found that ADAM8 (CD 156...

Subject

Neurodegeneration

Disintegrin

Cell biology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!